Journal article
Appraising the relevance of DNA copy number loss and gain in prostate cancer using whole genome DNA sequence data
- Abstract:
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A variety of models have been proposed to explain regions of recurrent somatic copy number alteration (SCNA) in human cancer. Our study employs Whole Genome DNA Sequence (WGS) data from tumor samples (n = 103) to comprehensively assess the role of the Knudson two hit genetic model in SCNA generation in prostate cancer. 64 recurrent regions of loss and gain were detected, of which 28 were novel, including regions of loss with more than 15% frequency at Chr4p15.2-p15.1 (15.53%), Chr6q27 (16.50%...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 5.7MB)
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- Publisher copy:
- 10.1371/journal.pgen.1007001
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Funding
Dallaglio Foundation
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Bob Champion Cancer Trust
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Bibliographic Details
- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PLoS genetics Journal website
- Volume:
- 13
- Issue:
- 9
- Pages:
- e1007001
- Publication date:
- 2017-09-25
- Acceptance date:
- 2017-08-28
- DOI:
- ISSN:
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1553-7404
- Pmid:
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28945760
- Source identifiers:
-
730888
Item Description
- Language:
- English
- Keywords:
- Pubs id:
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pubs:730888
- UUID:
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uuid:36802b57-60a1-4152-93a9-da4fea526c62
- Local pid:
- pubs:730888
- Deposit date:
- 2017-11-16
Terms of use
- Copyright holder:
- Camacho et al
- Copyright date:
- 2017
- Notes:
-
© 2017 Camacho et al. This is an open
access article distributed under the terms of the
Creative Commons Attribution License, which
permits unrestricted use, distribution, and
reproduction in any medium, provided the original
author and source are credited.
- Licence:
- CC Attribution (CC BY)
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