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Exome Chip Meta-analysis Fine Maps Causal Variants and Elucidates the Genetic Architecture of Rare Coding Variants in Smoking and Alcohol Use

Abstract:

BACKGROUND:Smoking and alcohol use have been associated with common genetic variants in multiple loci. Rare variants within these loci hold promise in the identification of biological mechanisms in substance use. Exome arrays and genotype imputation can now efficiently genotype rare nonsynonymous and loss of function variants. Such variants are expected to have deleterious functional consequences and to contribute to disease risk. METHODS:We analyzed ∼250,000 rare variants from 16 independent...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.biopsych.2018.11.024

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Institution:
University of Oxford
Division:
Social Sciences Division
Department:
Sociology
Department:
Unknown
Role:
Author
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Publisher:
Elsevier Publisher's website
Journal:
Biological Psychiatry Journal website
Volume:
85
Issue:
11
Pages:
946-955
Publication date:
2018-12-06
Acceptance date:
2018-11-28
DOI:
ISSN:
0006-3223 and 1873-2402
Pmid:
30679032
Source identifiers:
966711
Language:
English
Keywords:
Pubs id:
pubs:966711
UUID:
uuid:36af498b-bb44-45ce-8232-51c90d7c24ad
Local pid:
pubs:966711
Deposit date:
2019-04-26

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