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Thesis

Physiological and biological mechanisms of bisphosphonate action

Abstract:

Bisphosphonates (BPs) are stable analogues of pyrophosphate widely used for the treatment of bone diseases characterised by increased bone resorption. Studies over the years have shown that the pharmacological potencies of BPs are dependent both on their binding affinities for bone mineral and on their inhibitory actions on osteoclasts. In addition, potential effects on other cell types present locally in the environment of skeletal tissues have been reported.

The present study syste...

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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Oxford college:
Wadham College
Role:
Author

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Role:
Supervisor
Role:
Supervisor
Publication date:
2011
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
Language:
English
Keywords:
Subjects:
UUID:
uuid:36b0439d-2f89-4c1e-8bb3-941b4e6ee847
Local pid:
ora:5798
Deposit date:
2011-10-21

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