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Correcting the standard errors of 2-stage residual inclusion estimators for Mendelian randomization studies

Abstract:

Mendelian randomization studies use genotypes as instrumental variables to test for and estimate the causal effects of modifiable risk factors on outcomes. Two-stage residual inclusion (TSRI) estimators have been used when researchers are willing to make parametric assumptions. However, researchers are currently reporting uncorrected or heteroscedasticity-robust standard errors for these estimates. We compared several different forms of the standard error for linear and logistic TSRI estimate...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/aje/kwx175

Authors


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Role:
Author
ORCID:
0000-0003-4655-4511
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Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
Clinical Trial Service Unit
Role:
Author
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Role:
Author
ORCID:
0000-0001-9094-2605
Publisher:
Oxford University Press Publisher's website
Journal:
American Journal of Epidemiology Journal website
Volume:
186
Issue:
9
Pages:
1104-1114
Publication date:
2017-06-01
Acceptance date:
2016-12-21
DOI:
EISSN:
1476-6256
ISSN:
0002-9262
Pmid:
29106476
Source identifiers:
747471
Language:
English
Keywords:
Pubs id:
pubs:747471
UUID:
uuid:36b82526-e8bb-457a-b1f7-0cac2bd6c3c6
Local pid:
pubs:747471
Deposit date:
2019-02-27

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