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Journal article

Identification of a functionally relevant adeno-associated virus Rep68 oligomeric interface.

Abstract:

The life cycle of the human parvovirus adeno-associated virus (AAV) is orchestrated by four Rep proteins. The large Rep proteins, Rep78 and Rep68, are remarkably multifunctional and display a range of biochemical activities, including DNA binding, nicking, and unwinding. Functionally, Rep78 and Rep68 are involved in transcriptional regulation, DNA replication, and genomic integration. Structurally, the Rep proteins share an AAA(+) domain characteristic of superfamily 3 helicases, with the lar...

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Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.1128/JVI.00356-16

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Jenner Institute
Role:
Author
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Contributors

Role:
Editor
Pfizer Rare Diseases Consortium More from this funder
Publisher:
American Society of Microbiology Publisher's website
Journal:
Journal of Virology Journal website
Volume:
90
Issue:
15
Pages:
6612-6624
Publication date:
2016-05-01
Acceptance date:
2016-05-01
DOI:
EISSN:
1098-5514
ISSN:
0022-538X
Source identifiers:
662408
Language:
English
Keywords:
Pubs id:
pubs:662408
UUID:
uuid:36ca4480-e3c0-4082-8fe8-07da2ff11676
Local pid:
pubs:662408
Deposit date:
2017-07-13

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