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Thesis

Investigating the epigenetic regulation of the eukaryotic centromere by the segregase enzyme p97

Abstract:

The centromere is a vital locus for mediating chromosome segregation. It defines the location where sister chromatids are joined, and constitutes the foundation of the kinetochore, facilitating microtubule binding in mitosis. The position of the centromere is defined by nucleosomes containing CENP-A, a centromere-specific histone which is a necessary and sufficient locus-specifying seed to facilitate deposition of further CENP-A nucleosomes via an epigenetic self-templating feedback loop. ...

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Division:
MSD
Department:
Biochemistry
Role:
Author

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Role:
Supervisor
Type of award:
MSc by Research
Level of award:
Masters
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
Deposit date:
2022-05-29

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