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GABAA receptor autoimmunity: a multicenter experience

Abstract:

Objective:We sought to validate methods for detection and confirmation of GABAA receptor (R)-IgG and clinically characterize seropositive cases. Methods:Archived serum and CSF specimens (185 total) suspected to harbor GABAAR-IgG were evaluated by indirect immunofluorescence assay (IFA). Twenty-six specimens from 19 patients appeared suspicious for GABAAR-IgG positivity by IFA, based on prior reports and comparison with commercial GABAAR antibody staining. Aliquots of those specimens were test...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1212/NXI.0000000000000552

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Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
ORCID:
0000-0003-4142-2667
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Publisher:
Wolters Kluwer Health Publisher's website
Journal:
Neurology Neuroimmunology and Neuroinflammation Journal website
Volume:
6
Issue:
3
Article number:
e552
Publication date:
2019-04-04
Acceptance date:
2019-02-14
DOI:
EISSN:
2332-7812
Pmid:
31119187
Source identifiers:
1002881
Language:
English
Keywords:
Pubs id:
pubs:1002881
UUID:
uuid:36d4c4e0-9554-4e19-abba-94ec590e4482
Local pid:
pubs:1002881
Deposit date:
2019-12-18

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