Contribution of polyol pathway to arteriolar dysfunction in hyperglycemia. Role of oxidative stress, reduced NO, and enhanced PGH(2)/TXA(2) mediation.

Journal article

Hyperglycemia increases glucose metabolism via the polyol pathway, which results in elevations of intracellular sorbitol concentration. Thus we hypothesized that elevated level of sorbitol contributes to the development of hyperglycemia-induced dysfunction of microvessels. In isolated, pressurized (80 mmHg) rat gracilis muscle arterioles (approximately 150 microm), high glucose treatment (25 mM) induced reduction in flow-dependent dilation (from maximum of 39 +/- 2% to 15 +/- 1%), which was s...

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Authors: Toth, E; Racz, A; Toth, J; Kaminski, P; Wolin, MS

• Publication status: Published
• Journal: American journal of physiology. Heart and circulatory physiology
• Volume: 293
• Issue: 5
• Pages: H3096-H3104
• Publication date: 2007-11-01
• DOI: 10.1152/ajpheart.01335.2006
• EISSN: 1522-1539
• ISSN: 0363-6135
• Language: English
• Keywords: Animals; Down-Regulation; Receptors, Thromboxane A2, Prostaglandin H2; Signal Transduction; Arterioles; Rats; Polymers; Rats, Wistar; Hyperglycemia; Nitric Oxide; Prostaglandin H2; Male; Oxidative Stress