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Contribution of polyol pathway to arteriolar dysfunction in hyperglycemia. Role of oxidative stress, reduced NO, and enhanced PGH(2)/TXA(2) mediation.

Abstract:

Hyperglycemia increases glucose metabolism via the polyol pathway, which results in elevations of intracellular sorbitol concentration. Thus we hypothesized that elevated level of sorbitol contributes to the development of hyperglycemia-induced dysfunction of microvessels. In isolated, pressurized (80 mmHg) rat gracilis muscle arterioles (approximately 150 microm), high glucose treatment (25 mM) induced reduction in flow-dependent dilation (from maximum of 39 +/- 2% to 15 +/- 1%), which was s...

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Publication status:
Published

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Publisher copy:
10.1152/ajpheart.01335.2006

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Journal:
American journal of physiology. Heart and circulatory physiology
Volume:
293
Issue:
5
Pages:
H3096-H3104
Publication date:
2007-11-01
DOI:
EISSN:
1522-1539
ISSN:
0363-6135
Source identifiers:
164466
Language:
English
Keywords:
Pubs id:
pubs:164466
UUID:
uuid:36da0103-9736-4e64-8bd6-21f7dcd2676d
Local pid:
pubs:164466
Deposit date:
2012-12-19

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