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Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission

Abstract:

Alpha synuclein aggregation plays a central role in Parkinson's disease pathology. Direct transmission of alpha synuclein from pathologically affected to healthy unaffected neurons may be important in the anatomical spread of the disease through the nervous system. We have demonstrated that exosomes released from alpha synuclein over-expressing SH-SY5Y cells contained alpha synuclein and these exosomes were capable of efficiently transferring alpha synuclein protein to normal SH-SY5Y cells. M...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.nbd.2011.01.029

Authors


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Institution:
University College London
Department:
University Department of Clinical Neurosciences,Institute of Neurology
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
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Institution:
University College London
Department:
University Department of Clinical Neurosciences,Institute of Neurology
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
Women's and Reproductive Health
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Women's and Reproductive Health
Role:
Author
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Funding agency for:
Alvarez-Erviti, L
Wellcome/MRC Parkinson's Disease Consortium More from this funder
Parkinson's Disease UK More from this funder
Department of Health More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Neurobiology of Disease Journal website
Volume:
42
Issue:
3
Pages:
360-367
Publication date:
2011-06-01
DOI:
ISSN:
0969-9961
Language:
English
Keywords:
Subjects:
UUID:
uuid:36e0b497-53ec-4daf-bb00-70f1a6d43d05
Local pid:
ora:5822
Deposit date:
2011-10-26

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