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The effect of the Interleukin-6-174G > C promoter gene polymorphism on endothelial function in healthy volunteers.

Abstract:

AIMS: Atherosclerosis is a chronic inflammatory condition, manifest in its early stages by endothelial dysfunction. Interleukin-6 (IL6) plays a key role in driving this process through stimulation of acute phase protein synthesis. We have examined the effect of the IL6 gene -174G > C promoter polymorphism on endothelial function in a group of healthy subjects. METHODS: 248 adults aged 20-28 years participated. Polymerase chain reaction was performed for the -174G > C polymorphism. Brach...

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
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Journal:
European journal of clinical investigation
Volume:
32
Issue:
3
Pages:
153-157
Publication date:
2002-03-01
DOI:
EISSN:
1365-2362
ISSN:
0014-2972
Source identifiers:
163874
Language:
English
Keywords:
Pubs id:
pubs:163874
UUID:
uuid:36e67737-e560-4ca6-9712-4147dff00e66
Local pid:
pubs:163874
Deposit date:
2012-12-19

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