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Diabetes mellitus and the β cell: the last ten years.

Abstract:

Diabetes is a major global problem. During the past decade, the genetic basis of various monogenic forms of the disease, and their underlying molecular mechanisms, have been elucidated. Many genes that increase type 2 diabetes (T2DM) risk have also been identified, but how they do so remains enigmatic. Nevertheless, defective insulin secretion emerges as the main culprit in both monogenic and polygenic diabetes, with environmental and lifestyle factors, via obesity, accounting for the current...

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Publication status:
Published

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Publisher copy:
10.1016/j.cell.2012.02.010

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
OCDEM
Role:
Author
Journal:
Cell
Volume:
148
Issue:
6
Pages:
1160-1171
Publication date:
2012-03-01
DOI:
EISSN:
1097-4172
ISSN:
0092-8674
Source identifiers:
320298
Language:
English
Keywords:
Pubs id:
pubs:320298
UUID:
uuid:36e7cf02-fa6e-4aad-bd8c-c0adb7022079
Local pid:
pubs:320298
Deposit date:
2012-12-19

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