Journal article
Dissecting features of epigenetic variants underlying cardiometabolic risk using full-resolution epigenome profiling in regulatory elements
- Abstract:
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Sparse profiling of CpG methylation in blood by microarrays has identified epigenetic links to common diseases. Here we apply methylC-capture sequencing (MCC-Seq) in a clinical population of ~200 adipose tissue and matched blood samples (Ntotal~400), providing high-resolution methylation profiling (>1.3 M CpGs) at regulatory elements. We link methylation to cardiometabolic risk through associations to circulating plasma lipid levels and identify lipid-associated CpGs with unique localizati...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Version of record, pdf, 977.8KB)
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- Publisher copy:
- 10.1038/s41467-019-09184-z
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Authors
Bibliographic Details
- Publisher:
- Springer Nature Publisher's website
- Journal:
- Nature Communications Journal website
- Volume:
- 10
- Issue:
- 1
- Article number:
- 1209
- Publication date:
- 2019-03-14
- Acceptance date:
- 2019-02-25
- DOI:
- EISSN:
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2041-1723
- Pmid:
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30872577
- Source identifiers:
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983381
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:983381
- UUID:
-
uuid:36ef2507-7987-46ed-b3ce-c20910caaff6
- Local pid:
- pubs:983381
- Deposit date:
- 2019-04-09
Terms of use
- Copyright holder:
- Allum, F et al
- Copyright date:
- 2019
- Notes:
- © The Author(s) 2019. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.
- Licence:
- CC Attribution (CC BY)
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