Journal article
A phylogenetic codon substitution model for antibody lineages
- Abstract:
-
Phylogenetic methods have shown promise in understanding the development ofbroadly neutralizing antibody lineages (bNAbs). However, the mutational process that generates these lineages – somatic hypermutation (SHM) – is biased by hotspot motifs, which violates important assumptions in most phylogenetic substitution models. Here, we develop a modified GY94-type substitution model that partially accounts for this context-dependency while preserving independence of sites during calculation. This...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
Bibliographic Details
- Publisher:
- Genetics Society of America Publisher's website
- Journal:
- Genetics Journal website
- Volume:
- 206
- Issue:
- 1
- Pages:
- 417-427
- Publication date:
- 2017-05-05
- Acceptance date:
- 2017-03-10
- DOI:
- EISSN:
-
1943-2631
- ISSN:
-
0016-6731
Item Description
- Pubs id:
-
pubs:685577
- UUID:
-
uuid:36f6c533-ea16-422d-8b9c-4a77ec298f97
- Local pid:
- pubs:685577
- Deposit date:
- 2017-03-14
Terms of use
- Copyright holder:
- Hoehn, Lunter and Pybus
- Copyright date:
- 2017
- Notes:
- Copyright © 2017 Hoehn et al. Available freely online through the author-supported open access option. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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