Journal article
Immunotherapy of chronic hepatitis C virus infection with antibodies against programmed cell death-1 (PD-1).
- Abstract:
-
Hepatitis C virus (HCV) persistence is facilitated by exhaustion of CD8+ T cells that express the inhibitory receptor programmed cell death 1 (PD-1). Blockade of PD-1 signaling improves in vitro proliferation of HCV-specific T lymphocytes, but whether antiviral function can be restored in infected individuals is unknown. To address this question, chimpanzees with persistent HCV infection were treated with anti-PD-1 antibodies. A significant reduction in HCV viremia was observed in one of thre...
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- Publisher copy:
- 10.1073/pnas.1312772110
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Bibliographic Details
- Journal:
- Proceedings of the National Academy of Sciences of the United States of America
- Volume:
- 110
- Issue:
- 37
- Pages:
- 15001-15006
- Publication date:
- 2013-09-01
- DOI:
- EISSN:
-
1091-6490
- ISSN:
-
0027-8424
- Source identifiers:
-
426212
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:426212
- UUID:
-
uuid:36ffe9b1-2356-4e8e-be7b-d8bd2fc86c7b
- Local pid:
- pubs:426212
- Deposit date:
- 2013-11-16
Terms of use
- Copyright date:
- 2013
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