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Effect of adjuvant chemotherapy with fluorouracil plus folinic acid or gemcitabine vs observation on survival in patients with resected periampullary adenocarcinoma: the ESPAC-3 periampullary cancer randomized trial.

Abstract:

CONTEXT: Patients with periampullary adenocarcinomas undergo the same resectional surgery as that of patients with pancreatic ductal adenocarcinoma. Although adjuvant chemotherapy has been shown to have a survival benefit for pancreatic cancer, there have been no randomized trials for periampullary adenocarcinomas. OBJECTIVE: To determine whether adjuvant chemotherapy (fluorouracil or gemcitabine) provides improved overall survival following resection. DESIGN, SETTING, AND PATIENTS: The Europ...

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Publication status:
Published

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Publisher copy:
10.1001/jama.2012.7352

Authors


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Journal:
JAMA
Volume:
308
Issue:
2
Pages:
147-156
Publication date:
2012-07-01
DOI:
EISSN:
1538-3598
ISSN:
0098-7484
Source identifiers:
344639

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