Cysteine supplementation reverses methionine restriction effects on rat adiposity: significance of stearoyl-coenzyme A desaturase.

Journal article

Stearoyl-CoA desaturase-1 (SCD1) is a key enzyme in fatty acid and energy metabolism, but little is known about its nutritional regulation. Dietary methionine restriction in rats decreases hepatic Scd1 mRNA and protein, increases energy expenditure, and decreases fat-pad mass/body-weight% (FM/BW%). In humans, plasma concentrations of the methionine product, cysteine, are associated with obesity. To determine which consequences of methionine-restriction are mediated by decreased cysteine avail...

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Authors: Elshorbagy, A; Valdivia-Garcia, M; Mattocks, D; Plummer, J; Smith, A

• Publication status: Published
• Journal: Journal of lipid research
• Volume: 52
• Issue: 1
• Pages: 104-112
• Publication date: 2011-01-01
• DOI: 10.1194/jlr.m010215
• EISSN: 1539-7262
• ISSN: 0022-2275
• Language: English
• Keywords: Methionine; Animals; Rats; Male; Adipokines; Rats, Inbred F344; Cysteine; Adiposity; Taurine; Body Weight; Stearoyl-CoA Desaturase