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The magnitude and kinetics of the mucosal HIV-specific CD8+ T lymphocyte response and virus RNA load in breast milk.

Abstract:

BACKGROUND: The risk of postnatal HIV transmission is associated with the magnitude of the milk virus load. While HIV-specific cellular immune responses control systemic virus load and are detectable in milk, the contribution of these responses to the control of virus load in milk is unknown. METHODS: We assessed the magnitude of the immunodominant GagRY11 and subdominant EnvKY9-specific CD8+ T lymphocyte response in blood and milk of 10 A*3002+, HIV-infected Malawian women throughout the pe...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pone.0023735

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Institution:
University of Oxford
Role:
Author
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Institution:
University of Oxford
Role:
Author
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Funding agency for:
Permar, SR
Grant:
K08AI087992
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Funding agency for:
Permar, SR
Grant:
K08AI087992
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Funding agency for:
Permar, SR
Grant:
K08AI087992
Pediatric Infectious Disease Society More from this funder
Doris Duke Foundation More from this funder
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Publisher:
Public Library of Science Publisher's website
Journal:
PloS one Journal website
Volume:
6
Issue:
8
Article number:
e23735
Publication date:
2011-01-01
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
Source identifiers:
175160
Language:
English
Keywords:
Pubs id:
pubs:175160
UUID:
uuid:370f63e3-e3de-4a0c-935f-9f28235bae29
Local pid:
pubs:175160
Deposit date:
2012-12-19

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