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Journal article

Variant PRC1 Complex-Dependent H2A Ubiquitylation Drives PRC2 Recruitment and Polycomb Domain Formation

Abstract:: Chromatin modifying activities inherent to polycomb repressive complexes PRC1 and PRC2 play an essential role in gene regulation, cellular differentiation, and development. However, the mechanisms by which these complexes recognize their target sites and function together to form repressive chromatin domains remain poorly understood. Recruitment of PRC1 to target sites has been proposed to occur through a hierarchical process, dependent on prior nucleation of PRC2 and placement of H3K27me3. H...
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Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Blackledge, N., Farcas, A., Kondo, T., King, H., McGouran, J., Hanssen, L., Ito, S., Cooper, S., Kondo, K., Koseki, Y., Ishikura, T., Long, H., Sheahan, T., Brockdorff, N., Kessler, B., Koseki, H., & Klose, R. (2014). Variant PRC1 Complex-Dependent H2A Ubiquitylation Drives PRC2 Recruitment and Polycomb Domain Formation. Cell, 157(6), 1445–1459.

MLA Style

Blackledge, N., et al. “Variant PRC1 Complex-Dependent H2A Ubiquitylation Drives PRC2 Recruitment and Polycomb Domain Formation.” Cell, vol. 157, no. 6, Elsevier, 2014, pp. 1445–59.

Chicago Style

Blackledge, N, A Farcas, T Kondo, H King, J McGouran, L Hanssen, S Ito, et al. 2014. “Variant PRC1 Complex-Dependent H2A Ubiquitylation Drives PRC2 Recruitment and Polycomb Domain Formation.” Cell 157 (6): 1445–59.
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Files:: Variant PRC1 complex-d...

(Version of record, pdf, 4.1MB)

Publisher copy:: 10.1016/j.cell.2014.05.004

Authors

+ Blackledge, N More by this author

Institution:

University of Oxford

Division:

MSD

Department:

Biochemistry

Role:

Author

+ Farcas, A More by this author

Role:

Author

+ Kondo, T More by this author

Role:

Author

+ King, H More by this author

Role:

Author

+ McGouran, J More by this author

Institution:

University of Oxford

Division:

MPLS

Department:

Chemistry

Sub department:

Organic Chemistry

Role:

Author

More authors...

Funding

+ Cancer Research UK More from this funder

Grant:

C28585/A10839

+ Wellcome Trust More from this funder

Grant:

WT081385

Lister Institute of Preventative Medicine More from this funder

European Molecular Biology Organization More from this funder

National Institute for Health Research More from this funder

More funders...

Bibliographic Details

Publisher:: Elsevier Publisher's website
Journal:: Cell Journal website
Volume:: 157
Issue:: 6
Pages:: 1445-1459
Publication date:: 2014-06-01
DOI:: 10.1016/j.cell.2014.05.004
EISSN:: 1097-4172
ISSN:: 0092-8674

Item Description

Language:: English
Keywords:: Histones

Protein Structure, Tertiary

Genes, Lethal

Polycomb Repressive Complex 1

Animals

Mice

CpG Islands

Genome-Wide Association Study

Polycomb Repressive Complex 2

Bone Development

Jumonji Domain-Containing Histone Demethylases

F-Box Proteins

Embryonic Stem Cells
Pubs id:: pubs:465852
UUID:: uuid:37141780-8ad2-435f-b22a-7a9b1929dd06
Local pid:: pubs:465852
Source identifiers:: 465852
Deposit date:: 2014-05-31

Terms of use

Copyright holder:: Blackledge et a;
Copyright date:: 2014
Notes:: Copyright © 2014 The Authors. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/3.0/).

Licence:: CC Attribution (CC BY)

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