Journal article
A novel approach to antigen-specific deletion of CTL with minimal cellular activation using alpha3 domain mutants of MHC class I/peptide complex.
- Abstract:
-
In this study, we have compared the effector functions and fate of a number of human CTL clones in vitro or ex vivo following contact with variant peptides presented either on the cell surface or in a soluble multimeric format. In the presence of CD8 coreceptor binding, there is a good correlation between TCR signaling, killing of the targets, and FasL-mediated CTL apoptosis. Blocking CD8 binding using alpha3 domain mutants of MHC class I results in much reduced signaling and reduced killing ...
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- Publication status:
- Published
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- Publisher copy:
- 10.1016/s1074-7613(01)00133-9
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Authors
Bibliographic Details
- Journal:
- Immunity
- Volume:
- 14
- Issue:
- 5
- Pages:
- 591-602
- Publication date:
- 2001-05-01
- DOI:
- EISSN:
-
1097-4180
- ISSN:
-
1074-7613
- Source identifiers:
-
31882
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:31882
- UUID:
-
uuid:372c8811-6340-4d23-af46-333056053374
- Local pid:
- pubs:31882
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2001
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