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Modelling the effects of temporal variations of blood flow in tumours

Abstract:

Solid tumours have highly irregular vasculatures that are constantly re-modelled, giving rise to spatio-temporal heterogeneity in the level of nutrients, metabolites, and drugs. Such variability requires cells to adapt, and is hypothesised to select for more aggressive cancer phenotypes. Risk spreading through spontaneous phenotypic variations is an ecological concept which is used to explain how species may survive in temporally varying environments. It allows individuals within a species...

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Division:
MPLS
Department:
Mathematical Institute
Role:
Author

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Contributor
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Supervisor
ORCID:
0000-0003-1771-5910
Role:
Supervisor
Role:
Supervisor
Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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