Journal article
Nitric oxide modulates cardiomyocyte pH control through a biphasic effect on sodium/hydrogen exchanger-1
- Abstract:
-
Aims: When activated, Na+/H+ exchanger-1 (NHE1) produces some of the largest ionic fluxes in the heart. NHE1-dependent H+ extrusion and Na+ entry strongly modulate cardiac physiology through the direct effects of pH on proteins and by influencing intracellular Ca2+ handling. To attain an appropriate level of activation, cardiac NHE1 must respond to myocyte-derived cues. Among physiologically im...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
Bibliographic Details
- Publisher:
- Oxford University Press Publisher's website
- Journal:
- Cardiovascular Research Journal website
- Volume:
- 116
- Issue:
- 12
- Pages:
- 1958-1971
- Publication date:
- 2019-11-19
- Acceptance date:
- 2019-11-10
- DOI:
- EISSN:
-
1755-3245
- ISSN:
-
0008-6363
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:1070842
- UUID:
-
uuid:374202f2-8b28-4e3b-9fe0-5746e9fb85f6
- Local pid:
- pubs:1070842
- Source identifiers:
-
1070842
- Deposit date:
- 2019-11-10
Terms of use
- Copyright holder:
- Richards et al.
- Copyright date:
- 2019
- Rights statement:
- © The Author(s) 2019. Published by Oxford University Press on behalf of the European Society of Cardiology. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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