Journal article
Genetic incorporation of olefin cross-metathesis reaction tags for protein modification
- Abstract:
-
Olefin cross-metathesis (CM) is a viable reaction for the modification of alkene-containing proteins. Although allyl sulfide or selenide side-chain motifs in proteins can critically enhance the rate of CM reactions, no efficient method for their site-selective genetic incorporation into proteins has been reported to date. Here, through the systematic evaluation of olefin-bearing unnatural amino acids for their metabolic incorporation, we have discovered S-allylhomocysteine (Ahc) as a genetica...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
+ Royal Society
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Funding agency for:
Davis, B
Grant:
Wolfson Research Merit Award
Cancer Research UK
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Engineering and Physical Sciences Research Council
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Bibliographic Details
- Publisher:
- American Chemical Society Publisher's website
- Journal:
- Journal of the American Chemical Society Journal website
- Volume:
- 140
- Issue:
- 44
- Pages:
- 14599-14603
- Publication date:
- 2018-10-16
- Acceptance date:
- 2018-10-16
- DOI:
- EISSN:
-
1520-5126
- ISSN:
-
0002-7863
- Pmid:
-
30371070
Item Description
- Language:
- English
- Pubs id:
-
pubs:935835
- UUID:
-
uuid:37436f1d-1c5b-46f1-8a9f-a295d54677ce
- Local pid:
- pubs:935835
- Source identifiers:
-
935835
- Deposit date:
- 2018-12-16
Terms of use
- Copyright holder:
- American Chemical Society
- Copyright date:
- 2018
- Notes:
- Copyright © 2018 American Chemical Society. This is the accepted manuscript version of the article. The final version is available online from American Chemical Society at: https://doi.org/10.1021/jacs.8b09433
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