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Evolution of a polymorphic regulatory element in interferon-gamma through transposition and mutation.

Abstract:

Mammalian transposable elements have intrinsic regulatory elements that can activate neighboring genes, and it is speculated that they can also carry extrinsic transactivating DNA sequences to new genomic locations. We have identified a polymorphic segment of the human interferon-gamma promoter region where two adjacent binding sites for NF-kappaB and NFAT originated from the insertion of an Alu element approximately 22-34 MYA. Both binding sites lie outside the Alu consensus sequence but wit...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Paediatrics
Role:
Author
Journal:
Molecular biology and evolution
Volume:
19
Issue:
6
Pages:
884-890
Publication date:
2002-06-01
DOI:
EISSN:
1537-1719
ISSN:
0737-4038
Source identifiers:
191028

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