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Thesis

Cavitation-enhanced delivery of therapeutics to solid tumors

Abstract:

Poor drug penetration through tumor tissue has emerged as a fundamental obstacle to cancer therapy. The solid tumor microenvironment presents several physiological abnormalities which reduce the uptake of intravenously administered therapeutics, including leaky, irregularly spaced blood vessels, and a pressure gradient which resists transport of therapeutics from the bloodstream into the tumor. Because of these factors, a systemically administered anti-cancer agent is unlikely to reach 100...

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Institution:
University of Oxford
Division:
MPLS
Department:
Engineering Science
Research group:
Biomedical Ultrasonics, Biotherapy & Biopharmaceuticals Laboratory (BUBBL); Fluidics and Biocomplexity Group (FBG)
Oxford college:
Lady Margaret Hall
Role:
Author

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Role:
Supervisor
Role:
Supervisor
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Funding agency for:
Rifai, B
Grant:
EP/F011547/1
EP/F033710/1
Publication date:
2011
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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