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Journal article

Uncoupling protein 2 haplotype does not affect human brain structure and function in a sample of community-dwelling older adults

Abstract:

Uncoupling protein 2 (UCP2) is a mitochondrial membrane protein that plays a role in uncoupling electron transport from adenosine triphosphate (ATP) formation. Polymorphisms of the UCP2 gene in humans affect protein expression and function and have been linked to survival into old age. Since UCP2 is expressed in several brain regions, we investigated in this study whether UCP2 polymorphisms might 1) affect occurrence of neurodegenerative or mental health disorders and 2) affect measures of br...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pone.0181392

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Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
Population Health
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
Psychiatry
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
Psychiatry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
Psychiatry
Role:
Author
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Funding agency for:
Suri, S
Grant:
1117747
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Funding agency for:
Filippini, N
Grant:
1117747
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Funding agency for:
Mahmood, A
Grant:
1117747
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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS One Journal website
Volume:
12
Issue:
8
Article number:
e0181392
Publication date:
2017-08-03
Acceptance date:
2017-06-21
DOI:
ISSN:
1932-6203
Source identifiers:
702864
Pubs id:
pubs:702864
UUID:
uuid:3759484b-b5e9-4a0f-af30-7712d13404ef
Local pid:
pubs:702864
Deposit date:
2017-08-04

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