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An expanded peripheral T cell population to a cytotoxic T lymphocyte (CTL)-defined, melanocyte-specific antigen in metastatic melanoma patients impacts on generation of peptide-specific CTLs but does not overcome tumor escape from immune surveillance in metastatic lesions.

Abstract:

It is not known if immune response to T cell-defined human histocompatibility leukocyte antigen (HLA) class I-restricted melanoma antigens leads to an expanded peripheral pool of T cells in all patients, affects cytotoxic T lymphocyte (CTL) generation, and correlates with anti-tumor response in metastatic lesions. To this end, a limiting dilution analysis technique was developed that allowed us to evaluate the same frequency of peptide-specific T cells as by staining T cells with HLA-peptide ...

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Publication status:
Published

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Publisher copy:
10.1084/jem.190.5.651

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Journal:
Journal of experimental medicine
Volume:
190
Issue:
5
Pages:
651-667
Publication date:
1999-09-01
DOI:
EISSN:
1540-9538
ISSN:
0022-1007
Source identifiers:
31545

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