Journal article
The kidney hepcidin/ferroportin axis controls iron reabsorption and determines the magnitude of kidney and systemic iron overload
- Abstract:
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The hepcidin/ferroportin axis controls systemic iron homeostasis by regulating iron acquisition from the duodenum and reticuloendothelial system, respective sites of iron absorption and recycling. Ferroportin is also abundant in the kidney, where it has been implicated in tubular iron reabsorption. However, it remains unknown whether endogenous hepcidin regulates ferroportin-mediated iron reabsorption under physiological conditions, and whether such regulation is important for kidney and/or s...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, 3.6MB)
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- Publisher copy:
- 10.1016/j.kint.2021.04.034
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Authors
Funding
Bibliographic Details
- Publisher:
- Elsevier Publisher's website
- Journal:
- Kidney International Journal website
- Volume:
- 100
- Issue:
- 3
- Pages:
- 559-569
- Publication date:
- 2021-05-12
- Acceptance date:
- 2021-04-22
- DOI:
- EISSN:
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1523-1755
- ISSN:
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0085-2538
Item Description
- Language:
- English
- Keywords:
- Pubs id:
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1178193
- Local pid:
- pubs:1178193
- Deposit date:
- 2021-05-24
Terms of use
- Copyright holder:
- International Society of Nephrology
- Copyright date:
- 2021
- Rights statement:
- Copyright 2021, International Society of Nephrology. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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