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The kidney hepcidin/ferroportin axis controls iron reabsorption and determines the magnitude of kidney and systemic iron overload

Abstract:

The hepcidin/ferroportin axis controls systemic iron homeostasis by regulating iron acquisition from the duodenum and reticuloendothelial system, respective sites of iron absorption and recycling. Ferroportin is also abundant in the kidney, where it has been implicated in tubular iron reabsorption. However, it remains unknown whether endogenous hepcidin regulates ferroportin-mediated iron reabsorption under physiological conditions, and whether such regulation is important for kidney and/or s...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.kint.2021.04.034

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
Publisher:
Elsevier Publisher's website
Journal:
Kidney International Journal website
Volume:
100
Issue:
3
Pages:
559-569
Publication date:
2021-05-12
Acceptance date:
2021-04-22
DOI:
EISSN:
1523-1755
ISSN:
0085-2538
Language:
English
Keywords:
Pubs id:
1178193
Local pid:
pubs:1178193
Deposit date:
2021-05-24

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