Journal article
Oncogenic Gata1 causes stage-specific megakaryocyte differentiation delay
- Abstract:
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The megakaryocyte/erythroid Transient Myeloproliferative Disorder (TMD) in newborns with Down Syndrome (DS) occurs when N-terminal truncating mutations of the hemopoietic transcription factor GATA1, that produce GATA1short protein (GATA1s), are acquired early in development. Prior work has shown that murine GATA1s, by itself, causes a transient yolk sac myeloproliferative disorder. However, it is unclear where in the hemopoietic cellular hierarchy GATA1s exerts its effects to produce this mye...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, 6.3MB)
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(Supplementary materials, 8.7MB)
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- Publisher copy:
- 10.3324/haematol.2019.244541
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Authors
Bibliographic Details
- Publisher:
- Ferrara Storti Foundation Publisher's website
- Journal:
- Haematologica Journal website
- Volume:
- 106
- Issue:
- 4
- Pages:
- 1106-1119
- Publication date:
- 2020-06-11
- Acceptance date:
- 2020-05-20
- DOI:
- EISSN:
-
1592-8721
- ISSN:
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0390-6078
- Pmid:
-
32527952
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
1112591
- Local pid:
- pubs:1112591
- Deposit date:
- 2020-06-22
Terms of use
- Copyright holder:
- Ferrata Storti Foundation
- Copyright date:
- 2020
- Rights statement:
- Copyright © 2020, Ferrata Storti Foundation. This paper is Open Access under a Creative Commons Attribution Non-Commercial licence.
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