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Journal article

Oncogenic Gata1 causes stage-specific megakaryocyte differentiation delay

Abstract:

The megakaryocyte/erythroid Transient Myeloproliferative Disorder (TMD) in newborns with Down Syndrome (DS) occurs when N-terminal truncating mutations of the hemopoietic transcription factor GATA1, that produce GATA1short protein (GATA1s), are acquired early in development. Prior work has shown that murine GATA1s, by itself, causes a transient yolk sac myeloproliferative disorder. However, it is unclear where in the hemopoietic cellular hierarchy GATA1s exerts its effects to produce this mye...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.3324/haematol.2019.244541

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Clinical Laboratory Sciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Role:
Author
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Publisher:
Ferrara Storti Foundation Publisher's website
Journal:
Haematologica Journal website
Volume:
106
Issue:
4
Pages:
1106-1119
Publication date:
2020-06-11
Acceptance date:
2020-05-20
DOI:
EISSN:
1592-8721
ISSN:
0390-6078
Pmid:
32527952
Language:
English
Keywords:
Pubs id:
1112591
Local pid:
pubs:1112591
Deposit date:
2020-06-22

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