Journal article
Deacetylation inhibition reverses PABPN1-dependent muscle wasting
- Abstract:
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Reduced poly(A)-binding protein nuclear 1 (PABPN1) levels cause aging-associated muscle wasting. PABPN1 is a multifunctional regulator of mRNA processing. To elucidate the molecular mechanisms causing PABPN1-mediated muscle wasting, we compared the transcriptome with the proteome in mouse muscles expressing short hairpin RNA to PABPN1 (shPab). We found greater variations in the proteome than in mRNA expression profiles. Protein accumulation in the shPab proteome was concomitant with reduced p...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 10.9MB)
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- Publisher copy:
- 10.1016/j.isci.2019.01.024
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Authors
Funding
Bibliographic Details
- Publisher:
- Elsevier Publisher's website
- Journal:
- iScience Journal website
- Volume:
- 12
- Pages:
- 318-332
- Publication date:
- 2019-01-22
- Acceptance date:
- 2019-01-15
- DOI:
- EISSN:
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2589-0042
- ISSN:
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2589-0042
- Source identifiers:
-
966936
Item Description
- Language:
- English
- Pubs id:
-
pubs:966936
- UUID:
-
uuid:377db5f1-abd1-45ce-91d1-dfc83db3b888
- Local pid:
- pubs:966936
- Deposit date:
- 2019-01-30
Terms of use
- Copyright holder:
- Olie et al
- Copyright date:
- 2019
- Notes:
- © 2019 The Author(s). This is an open access article under the CC BY-NC-ND license.
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