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Journal article

Initiating and cancer-propagating cells in TEL-AML1-associated childhood leukemia.

Abstract:

Understanding cancer pathogenesis requires knowledge of not only the specific contributory genetic mutations but also the cellular framework in which they arise and function. Here we explore the clonal evolution of a form of childhood precursor-B cell acute lymphoblastic leukemia that is characterized by a chromosomal translocation generating a TEL-AML1 fusion gene. We identify a cell compartment in leukemic children that can propagate leukemia when transplanted in mice. By studying a monocho...

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Publication status:
Published

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Publisher copy:
10.1126/science.1150648

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Journal:
Science (New York, N.Y.)
Volume:
319
Issue:
5861
Pages:
336-339
Publication date:
2008-01-01
DOI:
EISSN:
1095-9203
ISSN:
0036-8075
Source identifiers:
66477

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