Journal article
Association of interleukin-1 gene polymorphisms with Alzheimer's disease.
- Abstract:
-
Interleukin-1 (IL-1) is markedly overexpressed in Alzheimer's disease. We found the IL-1A 2,2 genotype in 12.9% of 232 neuropathologically confirmed Alzheimer's disease patients and 6.6% of 167 controls from four centers in the United Kingdom and United States (odds ratio, 3.0; controlled for age and for ApoE [apolipoprotein E] genotype). Homozygosity for both allele 2 of IL-1A and allele 2 of IL-1B conferred even greater risk (odds ratio, 10.8). IL-1 genotypes may confer risk for Alzheimer's...
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- Publication status:
- Published
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- Publisher copy:
- 10.1002/1531-8249(200003)47:3<365::aid-ana13>3.3.co;2-7
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Authors
Bibliographic Details
- Journal:
- Annals of neurology
- Volume:
- 47
- Issue:
- 3
- Pages:
- 365-368
- Publication date:
- 2000-03-01
- DOI:
- EISSN:
-
1531-8249
- ISSN:
-
0364-5134
- Source identifiers:
-
60801
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:60801
- UUID:
-
uuid:3783fdf4-503a-41a1-ad5c-8460d74f60f2
- Local pid:
- pubs:60801
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2000
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