Journal article icon

Journal article

Association of interleukin-1 gene polymorphisms with Alzheimer's disease.

Abstract:

Interleukin-1 (IL-1) is markedly overexpressed in Alzheimer's disease. We found the IL-1A 2,2 genotype in 12.9% of 232 neuropathologically confirmed Alzheimer's disease patients and 6.6% of 167 controls from four centers in the United Kingdom and United States (odds ratio, 3.0; controlled for age and for ApoE [apolipoprotein E] genotype). Homozygosity for both allele 2 of IL-1A and allele 2 of IL-1B conferred even greater risk (odds ratio, 10.8). IL-1 genotypes may confer risk for Alzheimer's...

Expand abstract
Publication status:
Published

Actions


Access Document


Authors


Expand authors...
Journal:
Annals of neurology
Volume:
47
Issue:
3
Pages:
365-368
Publication date:
2000-03-01
DOI:
EISSN:
1531-8249
ISSN:
0364-5134
Source identifiers:
60801
Language:
English
Keywords:
Pubs id:
pubs:60801
UUID:
uuid:3783fdf4-503a-41a1-ad5c-8460d74f60f2
Local pid:
pubs:60801
Deposit date:
2012-12-19

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP