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Deuterium-reinforced polyunsaturated fatty acids protect against atherosclerosis by lowering lipid peroxidation and hypercholesterolemia

Abstract:

Background and aims Oxidative modification of lipoproteins is a crucial step in atherosclerosis development. Isotopic-reinforced polyunsaturated fatty acids (D-PUFAs) are more resistant to reactive oxygen species-initiated chain reaction of lipid peroxidation than regular hydrogenated (H-)PUFAs. We aimed at investigating the effect of D-PUFA treatment on lipid peroxidation, hypercholesterolemia and atherosclerosis development. Methods Transgenic APOE*3-Leiden.CETP mice, a well-established ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.atherosclerosis.2017.06.916

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Publisher:
Elsevier Publisher's website
Journal:
Atherosclerosis Journal website
Volume:
264
Pages:
100-107
Publication date:
2017-06-21
Acceptance date:
2017-06-20
DOI:
ISSN:
0021-9150
Source identifiers:
702205
Keywords:
Pubs id:
pubs:702205
UUID:
uuid:378458c5-65e0-4891-bb60-cc458455b81b
Local pid:
pubs:702205
Deposit date:
2017-06-29

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