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COMT val158met genotype affects recruitment of neural mechanisms supporting fluid intelligence.

Abstract:

Fluid intelligence (g(f)) influences performance across many cognitive domains. It is affected by both genetic and environmental factors. Tasks tapping g(f) activate a network of brain regions including the lateral prefrontal cortex (LPFC), the presupplementary motor area/anterior cingulate cortex (pre-SMA/ACC), and the intraparietal sulcus (IPS). In line with the "intermediate phenotype" approach, we assessed effects of a polymorphism (val(158)met) in the catechol-O-methyltransferase (COMT) ...

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Publication status:
Published

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Publisher copy:
10.1093/cercor/bhm240

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Institution:
University of Oxford
Division:
MSD
Department:
Experimental Psychology
Role:
Author
Journal:
Cerebral cortex (New York, N.Y. : 1991)
Volume:
18
Issue:
9
Pages:
2132-2140
Publication date:
2008-09-01
DOI:
EISSN:
1460-2199
ISSN:
1047-3211
Source identifiers:
383289
Language:
English
Keywords:
Pubs id:
pubs:383289
UUID:
uuid:3789b3a2-7bbf-4674-94d3-c39d8bc7e362
Local pid:
pubs:383289
Deposit date:
2013-11-16

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