Journal article
Modeling spinal muscular atrophy in Drosophila.
- Abstract:
-
Spinal Muscular Atrophy (SMA), a recessive hereditary neurodegenerative disease in humans, has been linked to mutations in the survival motor neuron (SMN) gene. SMA patients display early onset lethality coupled with motor neuron loss and skeletal muscle atrophy. We used Drosophila, which encodes a single SMN ortholog, survival motor neuron (Smn), to model SMA, since reduction of Smn function leads to defects that mimic the SMA pathology in humans. Here we show that a normal neuromuscular jun...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Version of record, pdf, 1006.4KB)
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- Publisher copy:
- 10.1371/journal.pone.0003209
Authors
Funding
National Institutes of Health
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SMA foundation
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Bibliographic Details
- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PloS one Journal website
- Volume:
- 3
- Issue:
- 9
- Pages:
- e3209
- Publication date:
- 2008-01-01
- DOI:
- EISSN:
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1932-6203
Item Description
- Language:
- English
- Keywords:
- UUID:
-
uuid:378a46b9-8eb0-4b69-9758-e1c22e01590e
- Local pid:
- pubs:268641
- Source identifiers:
-
268641
- Deposit date:
- 2012-12-19
Terms of use
- Copyright holder:
- Chang et al
- Copyright date:
- 2008
- Notes:
- Copyright 2008 Chang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
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