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Evidence that glutamate acting on presynaptic type-II metabotropic glutamate receptors alone does not fully account for the phenomenon of depolarisation-induced suppression of inhibition in cerebellar Purkinje cells.

Abstract:

Depolarisation-induced suppression of inhibition (DSI) is a form of short-term synaptic plasticity at gamma-aminobutyric-acid-(GABA)ergic synapses between principal neurons and interneurons in both the cerebellum and the hippocampus. The induction of DSI involves an intracellular calcium-dependent release of a retrograde messenger from the postsynaptic principal neuron (Purkinje cell/pyramidal cell in cerebellum/hippocampus) onto presynaptic interneurons, where it is thought to bind to guanin...

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Publication status:
Published

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Publisher copy:
10.1007/s004240100559

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
Journal:
Pflugers Archiv : European journal of physiology
Volume:
442
Issue:
3
Pages:
404-408
Publication date:
2001-06-01
DOI:
EISSN:
1432-2013
ISSN:
0031-6768
Source identifiers:
113880
Language:
English
Keywords:
Pubs id:
pubs:113880
UUID:
uuid:3793a623-f2b0-4fc1-8797-823421960625
Local pid:
pubs:113880
Deposit date:
2012-12-19

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