Loss of hippocampal serine protease BSP1/neuropsin predisposes to global seizure activity.

Journal article

Serine proteases in the adult CNS contribute both to activity-dependent structural changes accompanying learning and to the regulation of excitotoxic cell death. Brain serine protease 1 (BSP1)/neuropsin is a trypsin-like serine protease exclusively expressed, within the CNS, in the hippocampus and associated limbic structures. To explore the role of this enzyme, we have used gene targeting to disrupt this gene in mice. Mutant mice were viable and overtly normal; they displayed normal hippocam...

Expand abstract

Authors: Davies, B; Kearns, I; Ure, J; Davies, C; Lathe, R

• Journal: Journal of neuroscience : the official journal of the Society for Neuroscience
• Volume: 21
• Issue: 18
• Pages: 6993-7000
• Publication date: 2001-09-01
• EISSN: 1529-2401
• ISSN: 0270-6474
• Language: English
• Keywords: Serine Endopeptidases; Seizures; Long-Term Potentiation; In Situ Hybridization; Mice; Stem Cells; Maze Learning; Animals; Mice, Knockout; Cell Line; Behavior, Animal; Mice, Inbred C57BL; Kallikreins; Electric Stimulation; Kainic Acid; RNA, Messenger; Excitatory Postsynaptic Potentials; Hippocampus; Gene Targeting; Action Potentials; Genetic Predisposition to Disease; Proto-Oncogene Proteins c-fos