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Study of cytokine induced neuropathology by high resolution proton NMR spectroscopy of rat urine.

Abstract:

Multiple sclerosis is a major cause of non-traumatic neurological disability. The identification of markers that differentiate disease progression is critical to effective therapy. A combination of NMR spectroscopic metabolic profiling of urine and statistical pattern recognition was used to detect focal inflammatory central nervous system (CNS) lesions induced by microinjection of a replication-deficient recombinant adenovirus expressing TNF-alpha or IL1-beta cDNA into the brains of Wistar r...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Role:
Author
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Journal:
FEBS letters
Volume:
568
Issue:
1-3
Pages:
49-54
Publication date:
2004-06-01
DOI:
EISSN:
1873-3468
ISSN:
0014-5793
Source identifiers:
131096
Language:
English
Keywords:
Pubs id:
pubs:131096
UUID:
uuid:3796fc10-07ca-4ef7-9226-5712b5f6184e
Local pid:
pubs:131096
Deposit date:
2012-12-19

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