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Large-scale GWAS reveals genetic architecture of brain white matter microstructure and genetic overlap with cognitive and mental health traits (n = 17,706)

Abstract:

Individual variations of white matter (WM) tracts are known to be associated with various cognitive and neuropsychiatric traits. Diffusion tensor imaging (DTI) and genome-wide single-nucleotide polymorphism (SNP) data from 17,706 UK Biobank participants offer the opportunity to identify novel genetic variants of WM tracts and explore the genetic overlap with other brain-related complex traits. We analyzed the genetic architecture of 110 tract-based DTI parameters, carried out genome-wide asso...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41380-019-0569-z

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Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
Clinical Trial Service Unit
Role:
Author
ORCID:
0000-0002-4516-5103
Publisher:
Springer Nature Publisher's website
Journal:
Molecular Psychiatry Journal website
Volume:
26
Issue:
8
Pages:
3943–3955
Publication date:
2019-10-30
Acceptance date:
2019-10-20
DOI:
EISSN:
1476-5578
ISSN:
1359-4184
Source identifiers:
1059802
Language:
English
Keywords:
Pubs id:
pubs:1059802
UUID:
uuid:37a144f7-44cf-4d8b-8e9e-76280949bd1b
Local pid:
pubs:1059802
Deposit date:
2019-10-03

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