Thesis
Synthesis of taurospongin A and other biologically active natural products
- Abstract:
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This thesis firstly describes a synthesis of the natural product taurospongin A, a potent DNA polymerase beta inhibitor. Sharpless asymmetric dihydroxylation on olefin E-1.60 followed by selective deoxygenation at C(2) via Barton‒McCombie reaction delivers the desired C(1)–C(10) carboxylic acid core. Subsequent esterification of the C(1)–C(10) fragment with C(1′)–C(25′) fatty acid furnishes the natural product in 13.5% yield.
The structure of an unnamed natural produ...
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Funding
Bibliographic Details
- Publication date:
- 2017
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
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uuid:37a34bc4-efb4-4a6b-9d44-a3ad1c8ae0be
- Local pid:
- ora:10849
- Deposit date:
- 2015-04-09
Terms of use
- Copyright holder:
- Wu, B
- Copyright date:
- 2012
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