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Cytokine profiles during invasive nontyphoidal Salmonella disease predict outcome in African children.

Abstract:

Nontyphoidal Salmonella is a leading cause of sepsis in African children. Cytokine responses are central to the pathophysiology of sepsis and predict sepsis outcome in other settings. In this study, we investigated cytokine responses to invasive nontyphoidal Salmonella (iNTS) disease in Malawian children. We determined serum concentrations of 48 cytokines with multiplexed immunoassays in Malawian children during acute iNTS disease (n = 111) and in convalescence (n = 77). Principal component a...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1128/cvi.00128-16

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Paediatrics
Role:
Author
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Contributors

Role:
Editor
GlaxoSmithKline More from this funder
Bill and Melinda Gates Foundation More from this funder
Publisher:
American Society for Microbiology Publisher's website
Journal:
Clinical and Vaccine Immunology Journal website
Volume:
23
Issue:
7
Pages:
601-609
Publication date:
2016-05-01
Acceptance date:
2016-05-07
DOI:
EISSN:
1556-679X
ISSN:
1556-6811
Pmid:
27170644
Source identifiers:
623178
Language:
English
Keywords:
Pubs id:
pubs:623178
UUID:
uuid:37a34d07-c4a0-4fd0-9ab5-a22da0cc9733
Local pid:
pubs:623178
Deposit date:
2017-10-17

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