Mills' and other isolated upper motor neurone syndromes: in vivo study with 11C-(R)-PK11195 PET.

Journal article

(11)C-(R)-PK11195 positron emission tomography (PET) was used to explore and delineate in vivo the cortical lesion in three clinically isolated upper motor neurone syndromes of similar presentation, with reference to the syndrome of progressive spastic hemiparesis first described by Mills. Three patients with isolated UMN syndromes underwent (11)C-(R)-PK11195 PET of the brain. One patient fulfilled criteria for PLS. Two others had clinical features similar to the cases described by Mills; one...

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Authors: Turner, M; Gerhard, A; Al-Chalabi, A; Shaw, C; Hughes, R

• Publication status: Published
• Journal: Journal of neurology, neurosurgery, and psychiatry
• Volume: 76
• Issue: 6
• Pages: 871-874
• Publication date: 2005-06-01
• DOI: 10.1136/jnnp.2004.047902
• EISSN: 1468-330X
• ISSN: 0022-3050
• Language: English
• Keywords: Tomography, X-Ray Computed; Isoquinolines; Humans; Positron-Emission Tomography; Frontal Lobe; Motor Neuron Disease; Adult; Middle Aged; Aged; Cluster Analysis; Brain; Male; Electromyography; Magnetic Resonance Imaging; Antineoplastic Agents; Imaging, Three-Dimensional; Spinal Cord; Female