Journal article
Human and murine steroid 5β-reductases (AKR1D1 and AKR1D4): Insights into the role of the catalytic glutamic acid
- Abstract:
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Mammalian steroid 5β-reductases belong to the Aldo-Keto Reductase 1D sub-family and are essential for the formation of A-ring 5β-reduced steroids. Steroid 5β-reduction is required for the biosynthesis of bile-acids and the metabolism of all steroid hormones that contain a Δ4-3-ketosteroid functionally to yield the 5β-reduced metabolites. In mammalian AKR1D enzymes the conserved catalytic tetrad found in all AKRs (Y55, H117, K84 and D50) has changed in that the conserved H117 is replaced with ...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Accepted manuscript, pdf, 575.4KB)
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- Publisher copy:
- 10.1016/j.cbi.2019.03.025
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Authors
Bibliographic Details
- Publisher:
- Oxford University Press Publisher's website
- Journal:
- Chemico-Biological Interactions Journal website
- Volume:
- 305
- Pages:
- 163-170
- Publication date:
- 2019-03-28
- Acceptance date:
- 2019-03-25
- DOI:
- EISSN:
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1872-7786
- ISSN:
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0009-2797
- Pmid:
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30928400
- Source identifiers:
-
992432
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:992432
- UUID:
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uuid:37b37932-ae96-41d2-be50-1516573aeccf
- Local pid:
- pubs:992432
- Deposit date:
- 2019-06-14
Terms of use
- Copyright holder:
- Elsevier
- Copyright date:
- 2019
- Rights statement:
- © 2019 Elsevier B.V. All rights reserved.
- Notes:
- This is the accepted manuscript version of the article, available under a Creative Commons, Attribution, Non-Commercial, Non-Derivatives licence. The final version is available online from Elsevier at: https://doi.org/10.1016/j.cbi.2019.03.025
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