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Human and murine steroid 5β-reductases (AKR1D1 and AKR1D4): Insights into the role of the catalytic glutamic acid

Abstract:

Mammalian steroid 5β-reductases belong to the Aldo-Keto Reductase 1D sub-family and are essential for the formation of A-ring 5β-reduced steroids. Steroid 5β-reduction is required for the biosynthesis of bile-acids and the metabolism of all steroid hormones that contain a Δ4-3-ketosteroid functionally to yield the 5β-reduced metabolites. In mammalian AKR1D enzymes the conserved catalytic tetrad found in all AKRs (Y55, H117, K84 and D50) has changed in that the conserved H117 is replaced with ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.cbi.2019.03.025

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Publisher:
Oxford University Press Publisher's website
Journal:
Chemico-Biological Interactions Journal website
Volume:
305
Pages:
163-170
Publication date:
2019-03-28
Acceptance date:
2019-03-25
DOI:
EISSN:
1872-7786
ISSN:
0009-2797
Pmid:
30928400
Source identifiers:
992432
Language:
English
Keywords:
Pubs id:
pubs:992432
UUID:
uuid:37b37932-ae96-41d2-be50-1516573aeccf
Local pid:
pubs:992432
Deposit date:
2019-06-14

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