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Local GABA concentration is related to network-level resting functional connectivity

Abstract:

Anatomically plausible networks of functionally inter-connected regions have been reliably demonstrated at rest, although the neurochemical basis of these ‘resting state networks’ is not well understood. In this study, we combined magnetic resonance spectroscopy (MRS) and resting state fMRI and demonstrated an inverse relationship between levels of the inhibitory neurotransmitter GABA within the primary motor cortex (M1) and the strength of functional connectivity across the resting motor net...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.7554/eLife.01465

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Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
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Publisher:
eLife Sciences Publications Publisher's website
Journal:
eLife Journal website
Volume:
2014
Issue:
3
Article number:
e01465
Publication date:
2014-03-25
Acceptance date:
2014-01-24
DOI:
EISSN:
2050-084X
Source identifiers:
458638
Language:
English
Keywords:
UUID:
uuid:37d2a76a-e46c-4157-a4f5-18d443370406
Local pid:
pubs:458638
Deposit date:
2014-06-17

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