Journal article icon

Journal article

Invariant NKT cells modulate the suppressive activity of IL-10-secreting neutrophils differentiated with serum amyloid A.

Abstract:

Neutrophils are the main effector cells during inflammation, but they can also control excessive inflammatory responses by secreting anti-inflammatory cytokines. However, the mechanisms that modulate their plasticity remain unclear. We now show that systemic serum amyloid A 1 (SAA-1) controls the plasticity of neutrophil differentiation. SAA-1 not only induced anti-inflammatory interleukin 10 (IL-10)-secreting neutrophils but also promoted the interaction of invariant natural killer T cells (...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1038/ni.1942

Authors


Expand authors...
Journal:
Nature immunology
Volume:
11
Issue:
11
Pages:
1039-1046
Publication date:
2010-11-01
DOI:
EISSN:
1529-2916
ISSN:
1529-2908
Source identifiers:
96026
Language:
English
Keywords:
Pubs id:
pubs:96026
UUID:
uuid:37e0812f-ed4e-429c-951e-d2dd266040d8
Local pid:
pubs:96026
Deposit date:
2012-12-19

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP