Journal article
The Dyslexia-susceptibility protein KIAA0319 inhibits axon growth through Smad2 signaling.
- Abstract:
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KIAA0319 is a transmembrane protein associated with dyslexia with a presumed role in neuronal migration. Here we show that KIAA0319 expression is not restricted to the brain but also occurs in sensory and spinal cord neurons, increasing from early postnatal stages to adulthood and being downregulated by injury. This suggested that KIAA0319 participates in functions unrelated to neuronal migration. Supporting this hypothesis, overexpression of KIAA0319 repressed axon growth in hippocampal and ...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 1.7MB)
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- Publisher copy:
- 10.1093/cercor/bhx023
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Authors
Funding
Portuguese Foundation for Science and Technology
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Norte Portugal Regional Operational Programme
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European Regional Development Fund
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Bibliographic Details
- Publisher:
- Oxford University Press Publisher's website
- Journal:
- Cerebral Cortex Journal website
- Volume:
- 27
- Issue:
- 3
- Pages:
- 1732-1747
- Publication date:
- 2017-03-01
- Acceptance date:
- 2017-01-18
- DOI:
- EISSN:
-
1460-2199
- ISSN:
-
1047-3211
- Pmid:
-
28334068
Item Description
- Language:
- English
- Keywords:
- Pubs id:
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pubs:688866
- UUID:
-
uuid:37fd18cf-26ad-40fd-9a77-484b9d452ac7
- Local pid:
- pubs:688866
- Deposit date:
- 2017-07-28
Terms of use
- Copyright holder:
- Velayos-Baeza et al
- Copyright date:
- 2017
- Notes:
- © The Author 2017. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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