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Journal article

The Dyslexia-susceptibility protein KIAA0319 inhibits axon growth through Smad2 signaling.

Abstract:

KIAA0319 is a transmembrane protein associated with dyslexia with a presumed role in neuronal migration. Here we show that KIAA0319 expression is not restricted to the brain but also occurs in sensory and spinal cord neurons, increasing from early postnatal stages to adulthood and being downregulated by injury. This suggested that KIAA0319 participates in functions unrelated to neuronal migration. Supporting this hypothesis, overexpression of KIAA0319 repressed axon growth in hippocampal and ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/cercor/bhx023

Authors


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Portuguese Foundation for Science and Technology More from this funder
Norte Portugal Regional Operational Programme More from this funder
European Regional Development Fund More from this funder
Publisher:
Oxford University Press Publisher's website
Journal:
Cerebral Cortex Journal website
Volume:
27
Issue:
3
Pages:
1732-1747
Publication date:
2017-03-01
Acceptance date:
2017-01-18
DOI:
EISSN:
1460-2199
ISSN:
1047-3211
Pmid:
28334068

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