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Journal article

Copy number, linkage disequilibrium and disease association in the FCGR locus.

Abstract:

The response of a leukocyte to immune complexes (ICs) is modulated by receptors for the Fc region of IgG (FcgammaRs), and alterations in their affinity or function have been associated with risk of autoimmune diseases, including systemic lupus erythematosus (SLE). The low-affinity FcgammaR genomic locus is complex, containing regions of copy number variation (CNV) which can alter receptor expression and leukocyte responses to IgG. Combined paralogue ratio tests (PRTs) were used to distinguish...

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Publication status:
Published

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Publisher copy:
10.1093/hmg/ddq216

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Journal:
Human molecular genetics
Volume:
19
Issue:
16
Pages:
3282-3294
Publication date:
2010-08-01
DOI:
EISSN:
1460-2083
ISSN:
0964-6906
Source identifiers:
58617

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