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Distinctive genetic structure and selection patterns in Plasmodium vivax from South Asia and East Africa

Abstract:

Despite the high burden of Plasmodium vivax malaria in South Asian countries, the genetic diversity of circulating parasite populations is not well described. Determinants of antimalarial drug susceptibility for P. vivax in the region have not been characterised. Our genomic analysis of global P. vivax (n = 558) establishes South Asian isolates (n = 92) as a distinct subpopulation, which shares ancestry with some East African and South East Asian parasites. Signals...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41467-021-23422-3

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Role:
Author
ORCID:
0000-0002-4313-4290
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Role:
Author
ORCID:
0000-0001-7405-6523
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Role:
Author
ORCID:
0000-0001-8323-7019
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Publisher:
Springer Nature Publisher's website
Journal:
Nature Communications Journal website
Volume:
12
Issue:
1
Article number:
3160
Publication date:
2021-05-26
Acceptance date:
2021-04-28
DOI:
EISSN:
2041-1723
ISSN:
2041-1723
Pmid:
34039976
Language:
English
Keywords:
Pubs id:
1180133
Local pid:
pubs:1180133
Deposit date:
2021-07-09

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