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Differential use of importin-α isoforms governs cell tropism and host adaptation of influenza virus

Abstract:

Influenza A viruses are a threat to humans due to their ability to cross species barriers, as illustrated by the 2009 H1N1v pandemic and sporadic H5N1 transmissions. Interspecies transmission requires adaptation of the viral polymerase to importin-α, a cellular protein that mediates transport into the nucleus where transcription and replication of the viral genome takes place. In this study, we analysed replication, host specificity and pathogenicity of avian and mammalian influenza viruses, ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/ncomms1158

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Publisher:
Springer Nature Publisher's website
Journal:
Nature Communications Journal website
Volume:
2
Article number:
156
Publication date:
2011-01-18
Acceptance date:
2010-12-08
DOI:
EISSN:
2041-1723
Source identifiers:
112548
Language:
English
Keywords:
UUID:
uuid:3818c50f-ec2e-454a-980e-3dc037ff7cb3
Local pid:
pubs:112548
Deposit date:
2012-12-19

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