Journal article
Differential use of importin-α isoforms governs cell tropism and host adaptation of influenza virus
- Abstract:
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Influenza A viruses are a threat to humans due to their ability to cross species barriers, as illustrated by the 2009 H1N1v pandemic and sporadic H5N1 transmissions. Interspecies transmission requires adaptation of the viral polymerase to importin-α, a cellular protein that mediates transport into the nucleus where transcription and replication of the viral genome takes place. In this study, we analysed replication, host specificity and pathogenicity of avian and mammalian influenza viruses, ...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 1.1MB)
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- Publisher copy:
- 10.1038/ncomms1158
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Authors
Bibliographic Details
- Publisher:
- Springer Nature Publisher's website
- Journal:
- Nature Communications Journal website
- Volume:
- 2
- Article number:
- 156
- Publication date:
- 2011-01-18
- Acceptance date:
- 2010-12-08
- DOI:
- EISSN:
-
2041-1723
- Source identifiers:
-
112548
Item Description
- Language:
- English
- Keywords:
- UUID:
-
uuid:3818c50f-ec2e-454a-980e-3dc037ff7cb3
- Local pid:
- pubs:112548
- Deposit date:
- 2012-12-19
Terms of use
- Copyright holder:
- Macmillan Publishers Limited
- Copyright date:
- 2011
- Notes:
- © 2011 Macmillan Publishers Limited. All rights reserved. This work is licensed under a Creative Commons Attribution-NonCommercialShare Alike 3.0 Unported License.
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