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Journal article

Cellular polarity modulates drug resistance in primary colorectal cancers via orientation of the multidrug resistance protein ABCB1

Abstract:

Colonic epithelial cells are highly polarised with a lumen‐facing apical membrane, termed the brush border, and a basal membrane in contact with the underlying extracellular matrix (ECM). This polarity is often maintained in cancer tissue in the form of neoplastic glands and has prognostic value. We compared the cellular polarity of several ex vivo spheroid colonic cancer cultures with their parental tumours and found that those grown as non‐attached colonies exhibited apical brush border pro...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1002/path.5179

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Oxford college:
Mansfield College
Role:
Author
ORCID:
0000-0002-1655-5137
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; Weatherall Inst of Molecular Medicine
Role:
Author
Publisher:
John Wiley and Sons, Ltd. Publisher's website
Journal:
Journal of Pathology Journal website
Volume:
247
Issue:
3
Pages:
293-304
Publication date:
2018-10-10
Acceptance date:
2018-10-02
DOI:
EISSN:
1096-9896
ISSN:
0022-3417
Pmid:
30306567
Source identifiers:
927671
Language:
English
Keywords:
Pubs id:
pubs:927671
UUID:
uuid:381a8220-42b4-471f-b933-667338dec489
Local pid:
pubs:927671
Deposit date:
2018-10-16

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