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Thesis

Iron controls the adaptive immune response

Abstract:

Adaptive immune responses require dynamic cellular reconfigurations as antigen-specific lymphocytes proliferate, acquire effector functions and generate immunological memory. Several metabolic pathways are co-opted during this process, but specific metabolites identified as important substrates are rarely systemically limiting. Iron deficiency affects a billion people worldwide and a mutation in transferrin receptor that disrupts the ability of lymphocytes to acquire iron causes immunodefi...

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Division:
MSD
Role:
Author

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Role:
Supervisor
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Grant:
HIU MRC Core grant awarded to Hal Drakesmith
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Subjects:
UUID:
uuid:38257fec-43bd-4cbf-b84a-b11f866ce23f
Deposit date:
2020-04-07

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